The house has named Christopher Lemaire - currently creative director of Lacoste - as his successor.
"Hermès is deeply grateful to Jean Paul Gaultier for his outstanding creative contribution during these seven years," the company told WWD.
Gaultier will leave after the label's spring/summer 2011 collection is showcased in October and Lemaire will take the helm at women's ready-to-wear at the start of the autumn/winter 2011 collection.
Gaultier, who was appointed artistic director of Hermès in 2003 when he took over from Martin Margiela, is expected to concentrate on his own ready-to-wear collections and haute couture fashion house, in which Hermès will retain a 45 per cent stake.
Hermès recently reported a sales increase of 18 per cent over the last quarter, and 15.2 per cent rise across Europe. The label plans to open or renovate 20 stores over the future year.